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KMID : 0376519860040000156
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Mental Health Research
1986 Volume.4 No. 0 p.156 ~ p.162
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Serum Immunoglobulins in Schizophrenic Patients
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楊秉煥/Yang, Byung-Hwan
南正鉉/Nam, Jung-Hyun
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Abstract
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A variety of immunologic abnormalities has been reported in con juction with mental illness, particularly schizophrenia. Though serum immunoglobulin classes in schizophrenic patients have been extensively investigated, research finding is still conflicting.
The authors determined serum levels of IgG, IgA and IgM by turbidimetric immunoassay in 12 newly admitted schizophrenic patients and 24 hL a lthy volunteers. Blood was collected from all patients within 24 hours after admission.
The authors found significantly higher´, mean serum levels of IgG in the schizophTe nics than the healthy controls, but there was no significant difference in mean IgA and Ig1Vj´´ levels between the two groups. The mean values of IgG, IgA, IgM in healthy controls were 1, 242202mg/dl, 20079mg/dl and 129 48mg/dl, respectively. The mean values of IgG, IgA, IgM in schizophrenics were 1,431 287mg/dl, 20171mg/dl and 13454mg/dl, respectively.
The levels of immunoglobulins found in our schizophrenic subjects are not generally outside the Korean normal range.
The authors discussed the possible reasons of these findings, and three possible expla nations were given as follows.
1. Small size of samples limits interpretation of the present results.
2. Increased serum IgG may be due to stress, secondary to the illness.
3. An elevated serum IgG may play an eti ological role in biological subgroups of scbi a zophrenia.
It was suggested that biological subgroup , of schizophrenia would be identified from immunoglobulin pattern in the future study.
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